Elucidation of factors regulating genomic modality in the determination of inactivating X chromosomes

In female mammalian cells, one of the two X chromosomes is randomly inactivated early in development, but the determining mechanism of inactivating X chromosome has not been elucidated. In this study, using female mouse embryonic stem cells that can induce X-chromosome inactivation, we will quantify structural aspects of DNA such as higher-order genomic structure and informational aspects of DNA such as transcription over time to elucidate the regulatory mechanism of inactivated X-chromosome determination.

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