Toward constitutive understanding of transcriptional bursting through epigenomic modification density and intramolecular interactions

Epigenomic modification of a nucleosome, which forms a liquid and/or solid supramolecular condensate in the cell nucleus, is one of the driving forces of gene transcription. However, little progress has been made in reconstructing and understanding the significance of defined epigenomic modifications in gene transcription at the nucleosome level. In this study, we aim to constitutively understand the aspects of human epigenome transcription through establishing an in vitro reconstitution system that can reproduce the switch mechanism of transcription, such as transcriptional burst and super-enhancer.

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