Chromosome organization by archaeal condensin and DNA supercoils

The SMC complex condensin is widely conserved from eukaryotes to prokaryotes and plays critical roles in chromosome compaction and segregation. It has been suggested that eukaryotic condensin and positive DNA supercoils affect each other to fold chromosomes. However, the detailed mechanism and evolutionary origin of this interplay remain elusive. To address this question, we will investigate how archaeal condensin cooperates with reverse gyrase, a peculiar thermophile-specific enzyme that introduces positive DNA supercoils.

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