Multimodal regulation of chromatin structure during mouse spermatogenesis
Mammalian spermatogenesis is an intricately orchestrated developmental process. Alterations in nuclear architecture are closely associated with epigenetic regulation and the spatial organization of chromatin, playing a crucial role in the precise waves of gene expression. Throughout spermatogenesis, the expression of lamin is specifically regulated at distinct differentiation stages and is hypothesized to exert a significant influence not only on nuclear morphological changes but also on the regulation of epigenome and spatial rearrangement of chromatin structure. This study aims to unravel the genomic modality governed by the intricate interplay between nuclear lamins, chromatin, and epigenome during mouse spermatogenesis.
So Maezawa Project Leader
- Faculty of Science and Technology, Tokyo University of Science