Organaization

Functional characterization of an SMC-like protein in Archaea

The Structural Maintenance of Chromosomes (SMC) protein family is a key player in genome organization and widely distributed from Bacteria to Eukarya. Curiously, a number of archaeal species lack canonical members of the SMC family but instead have SMC-like proteins whose functions are totally unknown. In this study, we will characterize one of these SMC-like proteins by combining biochemistry and NGS (ChIP-seq, Hi-C, and HiChIP) techniques. This study will shed light on the overlooked diversity of SMC functions and the universal mechanisms underlying the diversity.


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