Roe of chromosome plasticity in chromosome segregation
The aim of this study is to focus on the plasticity of mitotic chromosomes and how this affects chromosome segregation. During mitosis, chromosomes are condensed and individualised, while they undergo significant morphological changes during chromosome segregation. However, the physical properties behind these morphological changes and their contribution to accurate chromosome segregation are not well understood. This study aims to clarify this point by observing chromosome morphological changes during mitosis in real time. The results of this study are expected to lead to a better understanding of genomic modality at the macro level, as well as a better understanding of the causes of chromosomal instability observed in many cancers.
Kozo Tanaka Project Leader
- Institute of Development, Aging and Cancer, Tohoku University