Deciphering the genome modality change through data-driven phase portrait reconstruction

The qualitative changes in life phenomena such as birth, death, cell differentiation, and carcinogenesis are realized by the elaborate gene expression control system of chromatin in the nucleus of eukaryotic cells. We have been established a sequence of methods to measure chromatin flow, which represents chromatin state changes, and computational methods to summarize of complex dynamics of cells as a phase diagram. In this project, we further aim to establish a framework to analyze and interpret high dimensional phase diagram to decipher qualitative traits, such as tissue regeneration and aging, from chromatin dynamics.


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