Multi-scale modeling of DNA mechanics

Due to its hierarchical structure, the behavior of DNA depends on the length scales, so does the model to describe it. In the scale comparable or smaller than the persistence length (~150 bp), the double-stranded DNA is modeled as an elastic rod with bending and twisting rigidities, where the precise estimate of the elastic constants is crucial for quantitative discussion of DNA mechanics. Here, we aim to connect the base-pair resolved microscopic DNA model with the more coarse-grained elastic model by elaborating on (1) the scale-dependent elastic constants and (2) the coupling among different degrees of freedom, and clarify their implications for e.g. DNA-protein interactions.

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