Genomic instability induced by specific spatial positions in the nucleus

It is well known that there are fragile sites in our genome, and many studies have characterized sequence motifs of these regions. Yet, it has not been well explained how DNA damage is specifically induced at fragile sites and how the diverse DNA mutations observed in clinics arise. This is partly due to the lack of positional-spatial information in the nucleus that is lost in the conventional mapping methods of sequencing results. In this study, we aim to develop a method for the simultaneous mapping of DNA damage and positional-spatial information in the nucleus. This new method will reveal how the fragility of our genome is associated with spatial positions in the nucleus, elucidating the strong relationship between mesoscale genome structure and genomic vulnerability.


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