Evaluation of physical properties of genomic DNA during cell differentiation
Genomic DNA exists inside the nucleus as a chromatin, which is a complex of DNA, RNA and proteins. The chromatin changes its structure and physical properties during development and differentiation, which should be critical for the expression of cell-specific genes. In this project, we focus on the mobility of genomic loci to understand how the structural and physical properties of genomic DNA change during development. While the mobility of genomic DNA is an emerging subject to understand the structure and physical properties of genomic DNA, little is still known about how the mobility changes during development and how the change reflect the changes in the structure and physical properties of genomic DNA. We utilize the method to analyze the mobility of genomic DNA developed by our group in the early embryos of C. elegans, and apply the method to understand the developmental change of genomic DNA.
Akatsuki Kimura Project Leader
- National Institute of Genetics